Modulatory effect of ginger on skeletal malformations, cell cycle, apoptosis and structural changes in the liver of rat fetuses prenatally exposed to labetalol

Abstract Background Drug-induced liver damage with clinical symptoms has been related to labetalol in a number of instances. In addition having wide range anti-inflammatory and antioxidant qualities, ginger also includes biotrace that are crucial the fight against disease skeletal deformity. this study, we hypothesized prenatal supplementation (200 mg/kg) attenuates malformation hepatotoxicity mediated by during organogenesis period. The tested dams were divided into four groups: control, mg/kg), (300 combined group (labetalol at same doses). Results showed various abnormalities represented mandibular hypoplasia, costal separation retardation ossification. Histological ultrastructural examination fetal tissue revealed multiple pathological changes. DNA damage, G0/G1 cell cycle arrest high percentage apoptosis detected hepatocytes from groups through gel electrophoresis flow cytometry using PI annexin V/PI methods, respectively. Administration after caused an evident decrease these malformations, structural changes, arrest. Conclusions It can be concluded great potential attenuating malformation, changes cyto-genotoxicity upon exposure labetalol.